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Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

✍ Scribed by Johan Wouters; Marjorie Huygens; Lionel Pochet; Bernard Pirotte; François Durant; Bernard Masereel


Book ID
108477176
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
263 KB
Volume
12
Category
Article
ISSN
0960-894X

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✍ Lionel Pochet; Marc Dieu; Raphaël Frédérick; Ann-Marie Murray; Isabelle Kempen; 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 226 KB

6-Chloromethylcoumarin derivatives are known to express a marked inhibitory potency against serine proteases. However, their mechanism of inhibition remains unclear. In order to confirm the postulated mechanism, we use mass spectrometry. The shift mass obtained after inactivation by two compounds, w