Investigation of the inhibition mechanis
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Lionel Pochet; Marc Dieu; Raphaël Frédérick; Ann-Marie Murray; Isabelle Kempen;
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Article
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2003
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Elsevier Science
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French
⚖ 226 KB
6-Chloromethylcoumarin derivatives are known to express a marked inhibitory potency against serine proteases. However, their mechanism of inhibition remains unclear. In order to confirm the postulated mechanism, we use mass spectrometry. The shift mass obtained after inactivation by two compounds, w