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Stabilization of peptide amides against α-chymotrypsin by the prodrug approach

✍ Scribed by A.M. Kahns; H. Bundgaard


Book ID
116108704
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
133 KB
Volume
21
Category
Article
ISSN
0168-3659

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The effects of trifluoroethanol (TFE) on the stability of the alpha-helix formed by ribonuclease S-peptide, residues 1-19 of ribonuclease A, were studied by measuring circular dichroism as a function of TFE concentration, pH, and temperature. The S-peptide forms an unusually stable alpha-helix, whic