Treatment of bafilomycin A 1 and isobafilomycin A 1 with triphenylphosphine and diethylazodicarboxylate under Mitsunobu conditions led to a fragmentation of the sugar-like ring to give the corresponding olefinic ester. The structure of the product from bafilomycin At was confirmed by single crystal
Structural and stereochemical homology between the macrolide and polyether antibiotics
β Scribed by David O'Hagan
- Book ID
- 104204166
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 374 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
As a result of the x-ray single crystal analysis of N-iodoacetylamphotericin B the chemical and stereochemical absolute structure ia presented (I). A similar etructure and stereochemistry wae extended to the parent compound itself, amphotericin B, a heptaene macrolide antifungal antibiotic possessin
Tetrahedron Letters No. 41. pp. 3601-3604 (1970) p. 3529 W. Sprenger was omitted from the "Contributors to this issue" W. MECHLINSKI, C. P. SCHAFFNER, P. GANIS and G. AVITABILE: Structure and absolute configuration of the polyene macrolide antibiotic amphotericin B.