Structural and spectral study of 7-bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one (bromazepam) platinum(II) dichloride bisdimethylsulfoxide
β Scribed by Adriano Benedetti; Antonio C. Fabretti; Carlo Preti; Giuseppe Tosi; Paolo Zannini
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 547 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1572-8854
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## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbonβ14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^Cβbenzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des
Immobilized CAL-B catalyzed kinetic resolution of syn-7-bromo-3-(1%-hydroxyethyl)-1-methyl-5-(2%-pyridyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one syn-(Β±)-2 and its anti-diastereomer (Β±)-3 were achieved with E-values over 200. Completely enantioselective acetylation of (1%R)-enantiomers in diastereome