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Structural and Kinetic Analysis of the Chemical Rescue of the Proton Transfer Function of Carbonic Anhydrase II †

✍ Scribed by Duda, David; Tu, Chingkuang; Qian, Minzhang; Laipis, Philip; Agbandje-McKenna, Mavis; Silverman, David N.; McKenna, Robert


Book ID
127357586
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
153 KB
Volume
40
Category
Article
ISSN
0006-2960

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Proton transfer pathways in the mutant H
✍ Arijit Roy; Srabani Taraphder 📂 Article 📅 2006 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 260 KB 👁 1 views

## Abstract We have investigated the possible proton transfer pathways from the surface of the protein to the zinc‐bound water molecule in the mutant His‐64–Ala of human carbonic anhydrase II. Starting with an input of known crystallographic structures of the mutant, we model the proton pathways as