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Structural and Biosynthetic Investigations of the Rubromycins

โœ Scribed by Carsten Puder; Shoshana Loya; Amnon Hizi; Axel Zeeck

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
317 KB
Volume
2000
Category
Article
ISSN
1434-193X

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โœฆ Synopsis

unclear. From the culture broth of the strain A1, in addition to 6, the co-metabolites ฮณ-rubromycin (3), ฮด-rubromycin (4) and 3ะˆ-hydroxy-ฮฒ-rubromycin (7) were isolated. Their structures were determined or confirmed by detailed spectroscopic analysis. The rubromycins inhibit HIV-1 reverse transcriptase (RT) and are cytostatically active against different tumor cell lines.

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