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Structural Analysis of the 5′Flanking Region of the β -globin Gene in African Sickle Cell Anemia Patients: Further Evidence for Three Origins of the Sickle Cell Mutation in Africa

✍ Scribed by Yahia Chebloune, Josée Pagnier, Guy Trabuchet, Claudine Faure, Gérard Verdier, Dominique Labie and Victor Nigon


Book ID
123635632
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
971 KB
Volume
85
Category
Article
ISSN
0027-8424

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Sequence polymorphisms within the 5'HS2 segment of human locus control region is described among sickle cell anemia patients. Distinct polymorphic patterns of a simple sequence repeat are observed in strong linkage disequilibrium with each of the five major beta s haplotypes. Potential functional re