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Structural analysis of recombinant soluble human interleukin-2 receptor primary structure, assignment of disulfide bonds and core IL-2 binding structure

✍ Scribed by May C. Miedel; Jeffrey D. Hulmes; David V. Weber; Pascal Bailon; Yu-Ching E. Pan


Book ID
115761389
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
452 KB
Volume
154
Category
Article
ISSN
0006-291X

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The characteristic CXC chemokine disulfide core of interleukin-8 (IL-8) has been rearranged in a variant replacing the 9-50 disulfide with a 9-38 disulfide. The new variant has been characterized by its binding affinity to IL-8 receptors A and B and the erythrocyte receptor DARC. This variant binds