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Limited tryptic digestion of recombinant human interleukin-2: Structure-binding relationships with the α chain of the interleukin-2 receptor

✍ Scribed by Kurt Hollfelder; Fariba Rabban; Feng Wang; Yu-Ching E. Pan

Publisher: Springer
Year: 1993
Tongue: English
Weight: 597 KB
Volume: 12
Category: Article
ISSN: 1573-4943
DOI: 10.1007/bf01025043

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## Abstract It has been previously demonstrated that human carcinomas express interleukin‐2 receptor (IL‐2R) α, β, and γ chains. The β and γ chains of IL‐2R have intermediate binding affinity for IL‐2 and are responsible for the intracellular signaling cascades after IL‐2 stimulation. IL‐2Rα lacks