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Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II

✍ Scribed by Srivastava, D. K.; Jude, Kevin M.; Banerjee, Abir L.; Haldar, Manas; Manokaran, Sumathra; Kooren, Joel; Mallik, Sanku; Christianson, David W.

Book ID
127142217
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
403 KB
Volume
129
Category
Article
ISSN
0002-7863

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## Abstract The 3‐dimensional structure of human carbonic anhydrase II (HCAII; EC 4.2.1.1) complexed with 3 structurally related inhibitors, __la, lb__, and __lc__, has been determined by X‐ray crystallographic methods. The 3 inhibitors (__la__ = C~8~H~12~N~2~O~4~S~3~) vary only in the length of th