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Stromal Targeting of Sodium Iodide Symporter Using Mesenchymal Stem Cells Allows Enhanced Imaging and Therapy of Hepatocellular Carcinoma

✍ Scribed by Knoop, Kerstin; Schwenk, Nathalie; Dolp, Patrick; Willhauck, Michael J.; Zischek, Christoph; Zach, Christian; Hacker, Markus; Göke, Burkhard; Wagner, Ernst; Nelson, Peter J.; Spitzweg, Christine

Book ID: 120547767
Publisher: Mary Ann Liebert
Year: 2013
Tongue: English
Weight: 574 KB
Volume: 24
Category: Article
ISSN: 1043-0342
DOI: 10.1089/hum.2012.104

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## Abstract ## Background. Gene therapy that uses delivery of the sodium‐iodide symporter (NIS) gene followed by radioiodide administration has been proposed as a novel form of radiotherapy for nonthyroidal cancers. ## Methods. In vitro [^125^I] iodide accumulation and efflux from cells was dete