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Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia

✍ Scribed by Jussi Hirvonen; Theo G.M. van Erp; Jukka Huttunen; Kjell Någren; Matti Huttunen; Sargo Aalto; Jouko Lönnqvist; Jaakko Kaprio; Tyrone D. Cannon; Jarmo Hietala


Book ID
113866038
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
163 KB
Volume
146
Category
Article
ISSN
0925-4927

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## Abstract In this study we examined the selectivity of dopamine (DA) for rat striatal DA D~1~ and D~2~ receptors. In a Krebs‐HEPES buffer, the K~i~ values of DA for D~1~ binding sites (labelled with [^3^H]SCH23390) and D~2~ binding sites (labelled with [^3^H]spiroperidol) in striatal membranes am