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Striatal and extrastriatal dopamine D2receptor occupancy by the partial agonist antipsychotic drug aripiprazole in the human brain: a positron emission tomography study with [11C]raclopride and [11C]FLB457

✍ Scribed by Takahata, Keisuke; Ito, Hiroshi; Takano, Harumasa; Arakawa, Ryosuke; Fujiwara, Hironobu; Kimura, Yasuyuki; Kodaka, Fumitoshi; Sasaki, Takeshi; Nogami, Tsuyoshi; Suzuki, Masayuki; Nagashima, Tomohisa; Shimada, Hitoshi; Kato, Motoichiro; Mimura, Masaru; Suhara, Tetsuya

Book ID
113021646
Publisher
Springer
Year
2012
Tongue
English
Weight
317 KB
Volume
222
Category
Article
ISSN
0033-3158

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## Abstract We used [^11^C]raclopride (RACLO) and positron emission tomography (PET) to study longitudinally striatal dopamine D~2~ receptor binding in nine patients with Parkinson's disease (PD) at an early drug‐naive stage and 3–5 years later, when motor fluctuations had appeared in seven of them