Stress Proteins

✍ Scribed by D. S. Latchman (auth.), Professor David S. Latchman M.A. Ph.D., D.Sc. (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 1999
Tongue: English
Leaves: 435
Series: Handbook of Experimental Pharmacology 136
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

✦ Table of Contents

Front Matter....Pages I-XXII
Stress Proteins: An Overview....Pages 1-7
The Hsp90 Chaperone Family....Pages 9-42
Heat Shock Protein 70....Pages 43-68
Mitochondrial Molecular Chaperones hsp60 and mhsp70: Are Their Roles Restricted to Mitochondria?....Pages 69-100
Role of Hsp27 and Related Proteins....Pages 101-132
Ubiquitin and the Stress Response....Pages 133-152
Regulation of Heat Shock Genes by Cytokines....Pages 153-171
Regulation of Heat Shock Genes by Ischemia....Pages 173-199
Regulation of Heat Shock Transcription Factors by Hypoxia or Ischemia/Reperfusion in the Heart and Brain....Pages 201-224
Autoregulation of the Heat Shock Response....Pages 225-241
The Cellular Stress Gene Response in Brain....Pages 243-263
Heat Stress Proteins and Their Relationship to Myocardial Protection....Pages 265-279
Heat Shock Proteins in Inflammation and Immunity....Pages 281-303
Heat Shock Proteins in Embryonic Development....Pages 305-327
Heat Shock Proteins in Rheumatoid Arthritis....Pages 329-346
Heat Shock Protein 60 and Type I Diabetes....Pages 347-361
Heat Shock Proteins and Multiple Sclerosis....Pages 363-380
Heat Shock Proteins in Atherosclerosis....Pages 381-402
Heat Shock Protein-Peptide Interaction: Basis for a New Generation of Vaccines Against Cancers and Intracellular Infections....Pages 403-414
Back Matter....Pages 415-422

✦ Subjects

Pharmacology/Toxicology; Cell Biology; Molecular Medicine; Immunology

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