Small Stress Proteins

✍ Scribed by Guido Kappé, Jack A. M. Leunissen, Wilfried W. de Jong (auth.), Professor Dr. André-Patrick Arrigo, W. E. G. Müller (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2002
Tongue: English
Leaves: 276
Series: Progress in Molecular and Subcellular Biology 28
Edition: 1
Category: Library

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✦ Synopsis

This book gives a comprehensive survey of the current knowledge of the expression and function of small stress proteins (sHsps) in different organisms, from prokaryotes to humans. It provides an overview of the diversity and complex evolutionary history of sHsps and describes their function and expression in different eukaryote models. Additional chapters discuss the role of sHsps in pathological conditions and gene therapy approaches towards a control of sHsp expression levels.

✦ Table of Contents

Front Matter....Pages I-XV
Evolution and Diversity of Prokaryotic Small Heat Shock Proteins....Pages 1-17
Discovery of Two Distinct Small Heat Shock Protein (HSP) Families in the Desert Fish Poeciliopsis ....Pages 19-35
Chaperone Function of sHsps....Pages 37-59
The Small Heat Shock Proteins of the Nematode Caenorhabditis elegans : Structure, Regulation and Biology....Pages 61-78
Drosophila Small Heat Shock Proteins: Cell and Organelle-Specific Chaperones?....Pages 79-101
The Developmental Expression of Small HSP....Pages 103-128
Expression and Phosphorylation of Mammalian Small Heat Shock Proteins....Pages 129-150
sHsp-Phosphorylation: Enzymes, Signaling Pathways and Functional Implications....Pages 151-169
Small Stress Proteins: Modulation of Intracellular Redox State and Protection Against Oxidative Stress....Pages 171-184
Small Stress Proteins: Novel Negative Modulators of Apoptosis Induced Independently of Reactive Oxygen Species....Pages 185-204
Hsp27 as a Prognostic and Predictive Factor in Cancer....Pages 205-218
Cytoskeletal Competence Requires Protein Chaperones....Pages 219-233
Hsp27 in the Nervous System: Expression in Pathophysiology and in the Aging Brain....Pages 235-251
Protection of Neuronal and Cardiac Cells by HSP27....Pages 253-265
Back Matter....Pages 267-270

✦ Subjects

Cell Biology; Biochemistry, general; Cancer Research; Animal Physiology

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