Stress Hormones and Post Traumatic Stress Disorder Basic Studies and Clinical Perspectives

✍ Scribed by E. Ronald De Kloet, Melly S. Oitzl and Eric Vermetten (Eds.)

• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Leaves: 298
• Series: Progress in Brain Research 167
• Edition: 1
• Category: Library

✦ Synopsis

Post-traumatic stress disorder (PTSD) arises from the experience of severe stressors and trauma. The disorder is characterized by recurrent recall of intrusive memories to the event, nightmares with insomnia, emotional numbing, hyperarousal, which are all long-lasting and relatively resistant to therapy. The focus of this book is on the question of how stress hormones are involved in PTSD. Recent evidence suggests that a dysregulation in stress hormones promotes the precipitation of PTSD and that correction of these hormones may ameliorate the disorder. This book combines state-of-the-art basic research on stress hormones from gene to behaviour with clinical research demonstrating the progress in understanding via imaging techniques, genetics, vulnerable phenotypes and co-morbidity with other disorders and physical illness.

✦ Table of Contents

Content:
List of contributors
Pages v-viii

Preface
Pages ix-xi
E. Ronald de Kloet, Melly S. Oitzl, Eric Vermetten

Acknowledgements
Page xiii

Stress-induced changes in hippocampal function Review Article
Pages 3-15
Marian Joëls, Harm Krugers, Henk Karst

Glucocorticoids, developmental ‘programming’ and the risk of affective dysfunction Review Article
Pages 17-34
Jonathan R. Seckl

Amygdala modulation of memory-related processes in the hippocampus: potential relevance to PTSD Review Article
Pages 35-51
M.M. Tsoory, R.M. Vouimba, I. Akirav, A. Kavushansky, A. Avital, G. Richter-Levin

Commentary: Neuroendocrine basis Review Article
Pages 53-62
E.R. de Kloet

Mice that under- or overexpress glucocorticoid receptors as models for depression or posttraumatic stress disorder Review Article
Pages 65-77
Sabine Chourbaji, Miriam A. Vogt, Peter Gass

Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences Review Article
Pages 79-97
Benno Roozendaal, Areg Barsegyan, Sangkwan Lee

Adult neurogenesis and systemic adaptation: animal experiments and clinical perspectives for PTSD Review Article
Pages 99-109
Noriko U. Takemura, Nobumasa Kato

Commentary: Behavioral phenotype Review Article
Pages 111-117
Melly S. Oitzl

Transgenerational transmission of cortisol and PTSD risk Review Article
Pages 121-135
Rachel Yehuda, Linda M. Bierer

Early care experiences and HPA axis regulation in children: a mechanism for later trauma vulnerability Review Article
Pages 137-149
Megan R. Gunnar, Karina M. Quevedo

The functional neuroanatomy of PTSD: a critical review Review Article
Pages 151-169
Israel Liberzon, Chandra Sekhar Sripada

Structural and functional plasticity of the human brain in posttraumatic stress disorder Review Article
Pages 171-186
J. Douglas Bremner, Bernet Elzinga, Christian Schmahl, Eric Vermetten

Commentary: biological findings in PTSD — too much or too little? Review Article
Pages 187-199
Arieh Y. Shalev, Ronen H. Segman

Models of PTSD and traumatic stress: the importance of research “from bedside to bench to bedside” Review Article
Pages 203-215
Robert J. Ursano, He Li, Lei Zhang, Chris J. Hough, Carol S. Fullerton, David M. Benedek, Thomas A. Grieger, Harry C. Holloway

What is it that a neurobiological model of PTSD must explain? Review Article
Pages 217-228
Chris R. Brewin

Post-traumatic stress disorder in somatic disease: lessons from critically ill patients Review Article
Pages 229-237
Gustav Schelling

Glucocorticoid-induced reduction of traumatic memories: implications for the treatment of PTSD Review Article
Pages 239-247
Dominique J.-F. de Quervain

Commentary: synthesis and perspectives Review Article
Pages 249-254
R.K. Pitman

Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice Review Article
Pages 257-261
V. Brinks, E.R. de Kloet, M.S. Oitzl

Interaction of endogenous cortisol and noradrenaline in the human amygdala Review Article
Pages 263-268
Anda H. van Stegeren, Oliver T. Wolf, Walter Everaerd, Serge A.R.B. Rombouts

Corticosteroid hormones, synaptic strength and emotional memories: corticosteroid modulation of memory — a cellular and molecular perspective Review Article
Pages 269-271
Olof Wiegert, Marian Joëls, Harm J. Krugers

Does trauma cause lasting changes in HPA-axis functioning in healthy individuals? Review Article
Pages 273-275
Ellen R. Klaassens, Tineke van Veen, Frans G. Zitman

Need for alternative ways of phenotyping of mood, anxiety, and somatoform disorders in biological research Review Article
Pages 277-280
G. Veen, I.M. van Vliet, R.H. de Rijk, F.G. Zitman

The HPA-axis and immune function in burnout Review Article
Pages 281-285
Paula M.C. Mommersteeg, Cobi J. Heijnen, Annemieke Kavelaars, Lorenz J.P. van Doornen

Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder Review Article
Pages 287-291
C.S. de Kloet, E. Vermetten, E. Geuze, E.G.W.M. Lentjes, C.J. Heijnen, G.K. Stalla, H.G.M. Westenberg

Precuneal activity during encoding in veterans with posttraumatic stress disorder Review Article
Pages 293-297
Elbert Geuze, Eric Vermetten, Carien S. de Kloet, Herman G.M. Westenberg

Posttraumatic stress disorder with secondary psychotic features: neurobiological findings Review Article
Pages 299-302
Mario H. Braakman, Frank A.M. Kortmann, Wim van den Brink, Robbert J. Verkes

Neuroendocrine dysregulations in sexually abused children and adolescents: a systematic review Review Article
Pages 303-306
I.A.E. Bicanic, M. Meijer, G. Sinnema, E.M. van de Putte, M. Olff

Volume of discrete brain structures in complex dissociative disorders: preliminary findings Review Article
Pages 307-310
T. Ehling, E.R.S. Nijenhuis, A.P. Krikke

Epilogue Review Article
Pages 311-313
Eric Vermetten

Subject Index
Pages 315-320