Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions

✍ Scribed by Jeremy Brown MA MB BS MRCP MD, Sven Hammerschmidt, Carlos Orihuela

• Publisher: Academic Press
• Year: 2015
• Tongue: English
• Leaves: 458
• Edition: 1
• Category: Library

✦ Synopsis

Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology.

It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections.

Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases.

• Provides an updated overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology
• Helps strengthen interdisciplinary networking and the focus of scientific resources by targeting epidemiology, vaccines, genetics, antibiotic resistance, clonal dissemination, Streptococcus pneumoniae biology, functional genomics, inflammasome, biomarkers, and more
• Multi-authored by leaders in the field who present a state-of-the-art overview of what the implications are of existing data, and the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections
• Supports combinatory networking in order to find new solutions in clinical therapies
• Reflects the most topical pneumococcal research trends

✦ Table of Contents

Content:
Front-matter, Pages i,iii
Copyright, Page iv
List of Contributors, Pages ix-xi, Vaibhav Agarwal, Simone Bergmann, Hester J. Bootsma, Jeremy S. Brown, Joáo A. Carriço, Scott Chancey, Dalia Denapaite, Hector D. de Paz, Dimitri A. Diavatopoulos, David H. Dockrell, Claire Durmort, Daniela M. Ferreira, Adam Finn, John P. Fobiwe, Sergio Galán-Bartual, Gustavo Gámez, Pedro García, Nicolas Gisch, Stephen B. Gordon, Nina Gratz, Anders P. Hakansson, et al.
Preface, Pages xiii-xvii
Chapter 1 - Molecular Epidemiology of Streptococcus pneumoniae, Pages 3-19, Mário Ramirez, Joáo A. Carriço, Mark van der Linden, José Melo-Cristino
Chapter 2 - Antibiotic Resistance of Pneumococci, Pages 21-40, Lesley McGee, Mathias W. Pletz, John P. Fobiwe, Keith P. Klugman
Chapter 3 - Pneumococcal Vaccination and Consequences, Pages 41-57, Hector D. de Paz, Laura Selva, Carmen Muñoz-Almagro
Chapter 4 - Vaccine Potential of Pneumococcal Proteins, Pages 59-78, Abiodun D. Ogunniyi, James C. Paton
Chapter 5 - Genomics, Genetic Variation, and Regions of Differences, Pages 81-107, Hervé Tettelin, Scott Chancey, Tim Mitchell, Dalia Denapaite, Yvonne Schähle, Martin Rieger, Regine Hakenbeck
Chapter 6 - Regulatory Strategies of the Pneumococcus, Pages 109-128, Colin C. Kietzman, Jason W. Rosch
Chapter 7 - Pneumococcal Genetic Transformation During Colonization and Biofilm Formation, Pages 129-142, Anders P. Hakansson, Laura R. Marks, Hazeline Roche-Hakansson
Chapter 8 - The Pneumococcal Cell Wall, Pages 145-167, Nicolas Gisch, Katharina Peters, Ulrich Zähringer, Waldemar Vollmer
Chapter 9 - Capsule Structure, Synthesis, and Regulation, Pages 169-179, Alistair J. Standish, Renato Morona
Chapter 10 - Streptococcus pneumoniae Lipoproteins and ABC Transporters, Pages 181-206, Claire Durmort, Jeremy S. Brown
Chapter 11 - Structure and Function of Choline-Binding Proteins, Pages 207-230, Sergio Galán-Bartual, Inmaculada Pérez-Dorado, Pedro García, Juan A. Hermoso
Chapter 12 - Non-Adhesive Surface Proteins of Streptococcus pneumoniae, Pages 231-244, Aldert Zomer, Peter W.M. Hermans, Hester J. Bootsma
Chapter 13 - Biofilm Formation Under In Vitro Conditions, Pages 245-255, Claudia Trappetti, Marco R. Oggioni
Chapter 14 - Pneumolysin, Pages 257-275, Daniel R. Neill, Timothy J. Mitchell, Aras Kadioglu
Chapter 15 - Nasopharyngeal Colonization with Streptococcus pneumoniae, Pages 279-291, Kirsty R. Short, Dimitri A. Diavatopoulos
Chapter 16 - Pneumococcal Biofilms and Bacterial Persistence During Otitis Media Infections, Pages 293-308, Melissa B. Oliver, W. Edward Swords
Chapter 17 - Pneumococcal Pili and Adhesins, Pages 309-346, Markus Hilleringmann, Sylvia Kohler, Gustavo Gámez, Sven Hammerschmidt
Chapter 18 - Exploitation of Host Signal Transduction Pathways Induced by Streptococcus pneumoniae, Pages 347-362, Simone Bergmann, Vaibhav Agarwal, Sven Hammerschmidt
Chapter 19 - Mechanisms of Predisposition to Pneumonia: Infants, the Elderly, and Viral Infections, Pages 363-382, Anthony J. Infante, Jonathan A. McCullers, Carlos J. Orihuela
Chapter 20 - Mechanisms Causing the Inflammatory Response to Streptococcus pneumoniae, Pages 383-400, Daniela M. Ferreira, Stephen B. Gordon
Chapter 21 - Streptococcus pneumoniae Interactions with Macrophages and Mechanisms of Immune Evasion, Pages 401-422, David H. Dockrell, Jeremy S. Brown
Chapter 22 - Cell-Mediated Immunity to the Pneumococcus, Pages 423-432, Adam Finn, Rick Malley
Chapter 23 - Pneumococcal Invasion: Development of Bacteremia and Meningitis, Pages 433-451, Nina Gratz, Lip Nam Loh, Elaine Tuomanen
Index, Pages 453-464