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πŸ“

Host-Pathogen Interactions in Streptococcal Diseases

✍ Scribed by Anna P. Ralph (auth.), G. Singh Chhatwal (eds.)


Publisher
Springer-Verlag Berlin Heidelberg
Year
2013
Tongue
English
Leaves
258
Series
Current Topics in Microbiology and Immunology 368
Edition
1
Category
Library

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✦ Synopsis


Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.

✦ Table of Contents


Front Matter....Pages i-viii
Group A Streptococcal Diseases and Their Global Burden....Pages 1-27
Molecular Markers for the Study of Streptococcal Epidemiology....Pages 29-48
Epidemiology and Pathogenicity of Zoonotic Streptococci....Pages 49-81
Adherence and Invasion of Streptococci to Eukaryotic Cells and their Role in Disease Pathogenesis....Pages 83-110
Common Regulators of Virulence in Streptococci....Pages 111-153
Host–Pathogen Interactions in Streptococcal Immune Sequelae....Pages 155-171
Immunopathogenesis of Streptococcal Deep Tissue Infections....Pages 173-188
Modulation of the Coagulation System During Severe Streptococcal Disease....Pages 189-205
Group A Streptococcal Vaccine Candidates: Potential for the Development of a Human Vaccine....Pages 207-242
Clinical Management of the Most Common Group A Ξ²-Hemolytic Streptococcal Infections....Pages 243-252
Back Matter....Pages 253-255

✦ Subjects


Medical Microbiology; Immunology; Vaccine; Molecular Medicine; Public Health; Bacteriology


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