Strategies for tolerance induction to composite tissue allografts
β Scribed by David W. Mathes; Mark A. Randolph; W.P. Andrew Lee
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 46 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0738-1085
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## Abstract Composite tissue allotransplantation (CTA) is the new frontier in transplantation. More than 25 hand allograft transplants have been performed worldwide, and the feasibility has been well established. The classical experimental model of CTA involves rat orthotopic hindlimb transplantati
## Abstract Recently, we induced donorβspecific tolerance to rat hindlimb allografts under a 35βday course of Ξ±Ξ²βTβcell receptor monoclonal antibody (Ξ±Ξ²βTCR mAb) and cyclosporine A (CsA). In this report, we investigated the role of shorter Ξ±Ξ²βTCR/CsA protocols on tolerance induction. We performed 5