Local drug delivery to composite tissue allografts
โ Scribed by Scott A. Gruber; Mansour V. Shirbacheh; Jon W. Jones; John H. Barker; Warren C. Breidenbach
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 43 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0738-1085
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This study was designed to evaluate the feasibility of applying locally delivered polylactic acid microspheres for drug delivery to the arterial wall. To study drug persistence, rhodamine-loaded microspheres were infused into one carotid artery of 14 rabbits and plain rhodamine solution into the oth
## Abstract Composite tissue allotransplantation (CTA) is the new frontier in transplantation. More than 25 hand allograft transplants have been performed worldwide, and the feasibility has been well established. The classical experimental model of CTA involves rat orthotopic hindlimb transplantati