Strategies for tolerance induction in nonhuman primates

✍ Scribed by Majed M Hamawy; Stuart J Knechtle

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 478 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80216-1

✦ Synopsis

Organ transplants in nonhuman primates provide a model which closely simulates the biological conditions of human organ transplantation, due to similarities between human and primate MHC (class I and II) structure and expression. Several strategies for tolerance induction have been developed in nonhuman primate models. These include targeting the T cell receptor or costimulatory molecules and the generation of mixed chimerism. Tolerance can be reliably induced in several such models, although none with 100% success.