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Strategies for the Synthesis of Fusicoccanes by Nazarov Reactions of Dolabelladienones: Total Synthesis of (+)-Fusicoauritone

✍ Scribed by David R. Williams; Leslie A. Robinson; C. Richard Nevill; Jayachandra P. Reddy

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
126 KB
Volume
46
Category
Article
ISSN
0044-8249

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The zaragozic acids and squalestatins, a novel family of fungal metabolites isolated and characterized by researchers at Merck [1] and Glaxo, [2] respectively, in 1992, are the most potent inhibitors of squalene synthase known to date. [3] Some members of this family have also demonstrated the abili