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Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy

✍ Scribed by Seiichi Nakamura; Yuuki Hirata; Takahiro Kurosaki; Masahiro Anada; Osamu Kataoka; Shinji Kitagaki; Shunichi Hashimoto

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 149 KB
Volume: 42
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200352629

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Total Synthesis of the Squalene Synthase

Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy

✍ Seiichi Nakamura; Yuuki Hirata; Takahiro Kurosaki; Masahiro Anada; Osamu Kataoka 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

The zaragozic acids and squalestatins, a novel family of fungal metabolites isolated and characterized by researchers at Merck [1] and Glaxo, [2] respectively, in 1992, are the most potent inhibitors of squalene synthase known to date. [3] Some members of this family have also demonstrated the abili

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