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Strain differences in the teratogenicity induced by sodium valproate in cultured mouse embryos

โœ Scribed by Naruse, Ichiro ;Collins, Michael D. ;Scott, William J.


Book ID
112217866
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
762 KB
Volume
38
Category
Article
ISSN
0040-3709

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The antiepileptic drug valproic acid is a well-known teratogenic agent; its main target organ is the neural tube, though skeletal malformations have also been described. In our recent work, respecifications of vertebrae were described in rat fetuses after treatment with 400 mg/kg of sodium valproate