✦ LIBER ✦

Strain differences in the immune response of mice to homologous sperm-specific lactate dehydrogenase (LDH-C4)

✍ Scribed by Kille, John W. ;Wheat, Thomas E. ;Mitchell, Graham ;Goldberg, Erwin

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 544 KB
Volume: 204
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402040213

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The sperm‐specific isozyme of murine lactate dehydrogenase (LDH‐C~4~ was injected into female mice of various strains. Two regulatory phenotypes characterize the resultant immunity to LDH‐C~4~: one is manifested by high, intermediate or low levels of response, the other by the immediate or delayed maturation of peak titer. The response of several strains can be classified as high (SWR, SJL, BABL/c, C3H/He) and intermediate to low (A, CBA, DBA/2, DBA/1, C57BL/6) according to the level of antibody production and cell mediated immunity. BALB/c, SJL and SWR strains are immediate responders while and C3H/He mice are clearly delayed responders. Maturation and magnitude of response do not appear to be related. Both the antibody and cell mediated responses are T‐dependent, but are not obviously associated with Ig allotype or H‐2 regulation.

📜 SIMILAR VOLUMES

Catalytic properties of the sperm-specif

Catalytic properties of the sperm-specific lactate dehydrogenase (LDH X or C4) from different species

✍ Coronel, Carlos E. ;Burgos, Carlos ;Gerez De Burgos, Nelia M. ;Rovai, Leonor E. 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 502 KB

A comparative study of catalytic properties of the sperm-specific lactate dehydrogenase (EC 1.1.1.27) isozyme X or C4 from a variety of animals (boar, bull, goat, Guinea pig, man, mouse, pigeon, rabbit, and rat) is presented. Optimum concentration and Km values for pyruvate, inhibition by substrate,

An allelic variant of the sperm-specific

An allelic variant of the sperm-specific lactate dehydrogenase C4 (LDH-X) isozyme in humans

✍ Wheat, Thomas E. ;Goldberg, Erwin 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 335 KB

## Abstract An unusual pattern of LDH isozymes was observed by gel electrophoresis of an extract of a human testis. This isozyme composition is consistent with an allelic variant of Ldh‐c.