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Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors

โœ Scribed by Hanane Elayadi; Michael Smietana; Christophe Pannecouque; Pieter Leyssen; Johan Neyts; Jean-Jacques Vasseur; Hassan B. Lazrek


Book ID
104005008
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
808 KB
Volume
20
Category
Article
ISSN
0960-894X

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A novel class of glucosyltransferase inhibitors has been designed and synthesised. The designed inhibitors 1-4 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The key synthetic steps involve a Michaelis-Arbuzov reaction followed by coupling with uridine-5%-morph