Straightforward Synthesis of 7$\alpha$-Methoxy-1-Oxacephems from Penicillins
โ Scribed by Nagata, W.
- Book ID
- 120152092
- Publisher
- The Royal Society
- Year
- 1980
- Tongue
- English
- Weight
- 638 KB
- Volume
- 289
- Category
- Article
- ISSN
- 0080-4622
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๐ SIMILAR VOLUMES
Reaction of penicillin sulfoxides with a tervalent phosphorous compound in the presence of a catalytic amount of squaric acid gave oxazolinoazetidinones, potential intermediates for synthesis of 1-oxacephems, in good yields. 2!3-Chloromethyl-and 6cr-methoxypenicillin sulfoxides also undergo this rea
Alcohols 4\_ and s prepared from 3 underwent completely stereospecific etherification to give l-oxacephams 2 and s which were converted into the 1-oxacephem nucleus 2 via kaand lc. Functionalization at C-3' in 6 and &was unsuccessful. Since 7a-methoxy-1-oxacephem & (6059-S) was found to be a highly