โ Scribed by Victor E. Kane
No coin nor oath required. For personal study only.
A multivariate Gaussian model for mammalian development is presented with the associated biological and mathematical assumptions. Many biological investigations use the female mammal X chromosome to test hypotheses and to estimate parameters of the developmental system. In particular, Lyon's (1961) hypotheses are used as a basis of the mathematical model. Experimental mouse data and three sets of human experimental data are analyzed using the hypothesized Gaussian model. The estimated biological parameters are consistent with some current biological theories.
๐ SIMILAR VOLUMES
X-chromosome inactivation refers to the coordinate regulation of almost all genes on the mammalian X chromosome. Most models for X chromosome inactivation suppose a role for methylation of X chromosome DNA sequences and/or the heterochromatinization of large 'domains' of the X chromosome containing