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Stimulatory effect of metoclopramide on the esophagus and lower esophageal sphincter of patients with pss

โœ Scribed by Manuel Ramirez-Mata; Graciela Ibanez; Donato Alarcon-Segovia

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
339 KB
Volume
20
Category
Article
ISSN
0004-3591

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โœฆ Synopsis

Abstract

Metoclopramide has been shown to stimulate motility of the gastrointestinal tract, including the esophagus. The authors therefore tested the effect of intravenous injections of metoclopramide on the sphincteric pressure and esophageal motility in 14 patients with esophageal dysfunction due to progressive systemic sclerosis (PSS). Isotonic saline similarly injected in a control period in 7 of the patients showed no effect. None of the 14 patients had a detectable pressure zone at the sphincteric area in basal conditions, but following the injection of metoclopramide, one appeared in 7 patients. Metoclopramide also caused the appearance of pressure waves in 5 of 11 patients who had aperistalsis, and caused up to a threefold increase in the amplitude of the pressure waves in the 3 patients who had hypomotility of the esophagus.

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โœ F. Jean; A. Aubert; F. Bloch; J. P. Petite; P. Priollet; J. N. Fiessinger; J. M. ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 234 KB ๐Ÿ‘ 2 views

We studied 22 patients with PSS who were treated with riifedipine for more than a year. The mean disease duration was 9.7 f 7.4 years. Digital ulcers were present in 12 patients when therapy was initiated. We wish to emphasize the dramatic beneficial effects of the drug on digital ulcerations; the u