Effects of diltiazem versus nifedipine on lower esophageal sphincter pressure in patients with progressive systemic sclerosis
✍ Scribed by F. Jean; A. Aubert; F. Bloch; J. P. Petite; P. Priollet; J. N. Fiessinger; J. M. Husson; E. Billaud
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 234 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
We studied 22 patients with PSS who were treated with riifedipine for more than a year. The mean disease duration was 9.7 f 7.4 years. Digital ulcers were present in 12 patients when therapy was initiated. We wish to emphasize the dramatic beneficial effects of the drug on digital ulcerations; the ulcers healed, and there were no recurrences.
When nifedipine was first administered, 11 of the 12 patients had esophageal involvement, which was detected by barium esophageal and fiberscopic studies. In 4 patients, there was a marked worsening of the lower esophageal tract function, with the appearance of reflux esophagitis. Therefore, our findings also demonstrate the potential adverse effects of nifedipine on some scleroderma-related symptoms. The seventy of esophageal involvement in patients with PSS who are being considered for nifedipine treatment should be considered prior to initiation of the drug.