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Stimulation of proinsulin biosynthesis by K+in rat pancreatic islets

✍ Scribed by Willy J. Malaisse; Ying Zhang; Jésus Cancelas; Pablo G. Prieto; Elisabeth Olivares; Maria L. Villanueva-Peñacarrillo; Isabel Valverde


Book ID
111637968
Publisher
Springer
Year
2004
Tongue
English
Weight
165 KB
Volume
23
Category
Article
ISSN
0969-711X

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The contribution of drug metabolites to cyproheptadine (CPH)induced alterations in endocrine pancreatic B-cells was investigated by examining the inhibitory activity of CPH and its biotransformation products, desmethylcyproheptadine (DMCPH), CPH-epoxide and DMCPH-epoxide, on hormone biosynthesis and