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Inhibition by kynurenine metabolites of proinsulin synthesis in isolated pancreatic islets

โœ Scribed by Noto, Yutaka ;Okamoto, Hiroshi

Book ID
110572447
Publisher
Springer-Verlag
Year
1978
Weight
586 KB
Volume
15
Category
Article
ISSN
0001-5563

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Cyproheptadine metabolites inhibit proin
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โœ Samson A. Chow; Josie L. Falany; Lawrence J. Fischer ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Springer ๐ŸŒ English โš– 906 KB

The contribution of drug metabolites to cyproheptadine (CPH)induced alterations in endocrine pancreatic B-cells was investigated by examining the inhibitory activity of CPH and its biotransformation products, desmethylcyproheptadine (DMCPH), CPH-epoxide and DMCPH-epoxide, on hormone biosynthesis and