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Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN

โœ Scribed by C. Peter Downes; Sarah Ross; Helene Maccario; Nevin Perera; Lindsay Davidson; Nick R. Leslie

Book ID
113418933
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
446 KB
Volume
47
Category
Article
ISSN
0065-2571

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Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes
โœ Manlio Vinciguerra; Antonino Sgroi; Christelle Veyrat-Durebex; Laura Rubbia-Bran ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 736 KB

Phosphatase and tensin homolog (PTEN) is a regulator of phosphoinositide 3-kinase signaling and an important tumor suppressor mutated/deleted in human cancers. PTEN deletion in the liver leads to insulin resistance, steatosis, inflammation, and cancer. We recently demonstrated that unsaturated fatty