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Stimulation of interleukin-6 production by corticotropin-releasing factor

✍ Scribed by Sy-Jye Christine Leu; Vijendra K. Singh

Book ID
113134894
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
579 KB
Volume
143
Category
Article
ISSN
0008-8749

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The mitogenic effect of corticotropin-releasing factor (CRF) on rat lymphocytes was investigated. When rat splenocytes were cultured for 48 hr with CFR, a dosedependent increase in incorporation of 3H-thymidine (3H-Tdr) was observed, with a maximal response at 10 nM CRF. Comparison of the proliferat