Stimulation of drug metabolism in man by tricyclic antidepressants
β Scribed by K. O'Malley; M. Browning; I. Stevenson; M. J. Turnbull
- Publisher
- Springer
- Year
- 1973
- Tongue
- English
- Weight
- 526 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0031-6970
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π SIMILAR VOLUMES
Because tricyclic antidepressants (TAD) are usually given chronically to patients, both their acute and their chronic effects on 5-hydroxytryptamine (5-HT) metabolism were studied. The probenecid method was used and, in addition to 5-hydroxy-indoleacetic acid (5-HIAA), some other indole compounds in
## Abstract Solidβphase microextraction coupled to liquid chromatography and mass spectrometry (SPMEβLCβMS) was used to analyze tricyclic antidepressant drugs desipramine, imipramine, nortriptyline, amitriptyline, and clomipramine (internal standard) in plasma samples. SPME was performed by direct