Stimulation of central D1 dopamine receptors reverses reserpine-induced hypothermia in mice
β Scribed by D. Duterte-Eoucher; Chantal Panissaud; A. Michael-Titus; J. Costentin
- Book ID
- 118956055
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 222 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0028-3908
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## Abstract To gain insight into the antiparkinsonian effects of selective D1 and D2 dopamine receptor stimulation, we examined the ability of D1 (SKF 38393) and D2 (quinpirole) agonists to reverse catalepsy induced by the combined administration of reserpine and Ξ±βmethylβpβtyrosine (AMPT) in rats.
In mice pretreated with reserpine plus alphamethyl-p-tyrosine, neither the D-2 selective agonist bromocriptine, nor the D-I selective agonist SKF38393, produced any measurable increase in locomotion in mice. However, the combination of the two agonists produced a marked and dose-dependent increase i