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Stimulation-induced inhibition of neuronal firing in human subthalamic nucleus

✍ Scribed by Mohammed Filali; WilliamD. Hutchison; VanessaN. Palter; AndresM. Lozano; JonathanO. Dostrovsky

Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
299 KB
Volume
156
Category
Article
ISSN
0014-4819

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FIG. 1. (A) Location of neuronal recording sites in a sagittal projection onto the Schaltenbrand Wahren atlas at the average laterality of 22 mm. (B) Mean firing rates in GPi and GPe are increased after STN-HFS. Box plots show median (line within the box) as well as 10, 25, 75, and 90th percentiles

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## Abstract Deep brain stimulation of the subthalamic nucleus (STN‐DBS) has become an effective treatment option in advanced Parkinson's disease (PD). Recent animal studies showed an increase of neuronal firing in dopaminergic neurons under effective STN‐DBS. Increased striatal dopamine levels may