High-frequency stimulation of the subthalamic nucleus increases pallidal neuronal firing rate in a patient with Parkinson's disease

✍ Scribed by René Reese; Frank Steigerwald; Monika Pötter; Jan Herzog; Günther Deuschl; Jens Volkmann; Marcus O. Pinsker; H. Maximilian Mehdorn

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 245 KB
• Volume: 23
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.22225

✦ Synopsis

FIG. 1. (A) Location of neuronal recording sites in a sagittal projection onto the Schaltenbrand Wahren atlas at the average laterality of 22 mm. (B) Mean firing rates in GPi and GPe are increased after STN-HFS. Box plots show median (line within the box) as well as 10, 25, 75, and 90th percentiles (*P < 0.05). The superimposed black dots represent the firing rate of each recorded neuron and the change before and after STN-HFS (line). (C) Band pass filtered spike train of an exemplary GPe neuron before, during and after STN-HFS (lower graph). Vertical black bars mark the beginning and end of STN-HFS (lower graph). The bar graph displays the instantaneous firing rate in one second bins (middle graph). To demonstrate the quality of spike separation an overlay of all sorted spikes (dark gray) and the stimulation artifact (light gray) is displayed above each of the three recording periods.