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Stimulation by extracellular ATP and UTP of the stress-activated protein kinase cascade in rat renal mesangial cells

✍ Scribed by Andrea Huwiler; Gerda Van Rossum; Markus Wartmann; Josef Pfeilschifter


Book ID
110002777
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
550 KB
Volume
120
Category
Article
ISSN
0007-1188

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Extracellular ATP-mediated phospholipase
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We investigated the mechanism of phospholipase A 2 (PLA 2 ) activation in response to the P2 receptor agonist ATP in rat thyroid FRTL-5 cells. The PLA 2 activity was determined by measuring the release of [ 3 H]-arachidonic acid (AA) from prelabeled cells. ATP evoked a dose-and time-dependent AA rel