Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells
โ Scribed by Andrea Huwiler; Markus Wartmann; Henk Van Den Bosch; Josef Pfeilschifter
- Book ID
- 110004784
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 367 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0007-1188
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## Abstract ## BACKGROUND The mitogenโactivated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and in human hepatocellular carcinoma
Recently identified c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase are activated by stimuli of various cellular stresses, cytokines, and growth factors. Strong activation of JNK was reported in the regenerating liver, implicating JNK in growth stimulation of hepatocytes. Howe