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Stimulation by EGF of the growth of EGF receptor-hyperproducing tumor cells in athymic mice

✍ Scribed by Soji Ozawa; Masakazu Ueda; Nobutoshi Ando; Osahiko Abe; Masamichi Hirai; Nobuyoshi Shimizu

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
505 KB
Volume
40
Category
Article
ISSN
0020-7136

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✦ Synopsis

EGF receptor-hyperproducing cells of squamous carcinoma origin were inoculated S.C. into the bilatero-abdominal regions of athymic mice and a mini-osmotic pump containing EGF was implanted on the back. After 2 weeks the tumors formed from 5 different cell lines in the presence of EGF weighed 3 to 6 times more than those formed in the absence of EGF. The cells recovered from these tumors maintained their original characteristics such as the amplified EGF receptor gene, high numbers of EGF receptors and a sensitivity to EGFmediated inhibition of growth in vitro. These results suggest that EGF plays an important role in promoting growth of squamous-cell carcinoma in vivo. ' To whom reprint requests should be addressed.

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