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Steroids XXIII. Synthesis of some ring a-fused heterocyclic steroids

✍ Scribed by Norman J. Doorenbos; Conrad P. Dorn Jr.


Publisher
John Wiley and Sons
Year
1965
Tongue
English
Weight
278 KB
Volume
54
Category
Article
ISSN
0022-3549

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A simple and efficient route to A-ring fused steroidal isothiazoles was developed. The key step involves C-S bond formation via substitution of a vinyl triflate at c-3. Prostate cancer is a common malignancy in the worldwide male population. Although hormonal therapies are commonly used, antiandroge