𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Steroid Total Synthesis, Part VII; (±)-estr-4-ene-3, 17-dione and (±) 13β-ethyl-gon-4-ene-3, 17-dione

✍ Scribed by M. Rosenberger; A. J. Duggan; G. Saucy

Publisher
John Wiley and Sons
Year
1972
Tongue
German
Weight
502 KB
Volume
55
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An efficient and practical synthesis of the title compounds is described. The novel route is based on earlier results and uses (±)‐5‐hydroxy‐9,9‐o‐phenylenedioxy‐decanoic acid lactone as the starting material. The results demonstrate the usefulness of pyrocatechol for the protection of an aliphatic ketone.

📜 SIMILAR VOLUMES

Steroid Total Synthesis, Part VIII; (+)-
Steroid Total Synthesis, Part VIII; (+)-estr-4-ene-3,17-dione
✍ M. Rosenberger; A. J. Duggan; R. Borer; R. Müller; G. Saucy 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 German ⚖ 807 KB

von Hand eingestellt werden. Die gleiche Teniperaturprogrammiereinheit steht hiebei im Temperaturintervall von 25 bis 60" in Stufen von 1" Abstand zur Verfiigung. Ein sclbstcntwickelter Tcmperaturregler mit Differentialeingang sorgt dafiir, dass die Temperaturiiberhohung des Luftthermostaten gegenii

An Efficient Synthesis of 11β-(4-Aminoph
An Efficient Synthesis of 11β-(4-Aminophenyl)spiro[estr-4-ene-17β,2′(5′H)-furan]-3,5′-dione
✍ Jens Geisler; Arwed Cleve; Michael Harre 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 94 KB

AbstractÐAn ef®cient synthesis has been developed affording 11b-(4-aminophenyl)spiro[estr-4-ene-17b,2 H (5 H H)-furan]-3,5 H -dione (2), main metabolite of antiprogestin (Z)-11b-[4-(dimethylamino)phenyl]-17b-hydroxy-17a-(3-hydroxyprop-1-enyl)estr-4-en-3-one (1), in an overall yield of 21%.

15α-Hydroxylation of 13-ethyl-gon-4-ene-
15α-Hydroxylation of 13-ethyl-gon-4-ene-3,17-dione using a hyphal fungus immobilized in calcium alginate gel beads
✍ D. Schlosser; Prof. Dr. H.-P. Schmauder 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 339 KB

Calcium alginate-entrapped mycelium of Penicillium raistrickii i 477 was used for the 15a-hydroxylation of 13-ethyl-gon-4-ene-3,17-dione. The system was tested in 10 batches during 40 days of operation, the catalytic activity could be completely regenerated by incubation in a nutrient medium between