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Steroid receptors in hereditary breast carcinomas associated with BRCA1 or BRCA2 mutations or unknown susceptibility genes

✍ Scribed by Niklas Loman; Oskar Johannsson; Pär-Ola Bendahl; Åke Borg; Mårten Fernö; Håkan Olsson

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
143 KB
Volume
83
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

The expression of steroid receptors is a common feature of both male and female breast carcinomas and is also one of the most important prognostic factors for patients with this disease. Steroid receptor levels in BRCA1related breast carcinoma have reportedly been low. Little data on steroid receptor levels have been reported with regard to BRCA2.

METHODS.

Steroid receptor levels were analyzed in 27 breast carcinomas associated with BRCA1 mutations, 14 associated with BRCA2 mutations, and 32 from individuals who had hereditary breast carcinoma but no detectable mutations of either BRCA1 or BRCA2. Breast carcinomas from 32 consecutive male patients, 6 of whom had mutations of BRCA2, were also examined for steroid receptors. Estrogen receptor (ER) and progesterone receptor (PgR) analyses were performed with radioligand or enzyme immunoassay techniques on tumor cytosol preparations.

Germline mutation screening and detection were performed using the protein truncation test, single strand conformation polymorphism, and direct sequencing on DNA from normal tissue.

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