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Steroid and non-steroid UDP glucuronyltransferase: Glucuronidation of synthetic estrogens as steroids

โœ Scribed by George W. Lucier; Otelia S. McDaniel

Book ID
116000651
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
690 KB
Volume
8
Category
Article
ISSN
0022-4731

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Valproic acid glucuronidation kinetics were carried our with three human UGT isoforms: UGT1A6, UGT1A9, and UGT2B7 as well as human liver and kidney microsomes. The glucuronidation of valproic acid was typified by high K(m) values with microsomes and expressed UGTs (2.3-5.2mM). The ability of valproi