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Cooxidation of steroidal and non-steroidal estrogens by purified prostaglandin synthase results in a stimulation of prostaglandin formation

✍ Scribed by G.H. Degen; J.A. McLachlan; T.E. Eling; K. Sivarajah

Book ID
116006407
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
798 KB
Volume
26
Category
Article
ISSN
0022-4731

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Prostaglandin H synthase (PSH) is known to metabolically activate a variety of xenobiotics in vitro by means of its peroxidase activity. Recently, stilbene and steroid estrogens have been found to be cooxidized by ram seminal vesical microsomes, a rich source of PHS, to nonextractable metabolites bo