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Sterile inflammatory responses mediated by the NLRP3 inflammasome

✍ Scribed by Suzanne L. Cassel; Fayyaz S. Sutterwala

Book ID
102167869
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
165 KB
Volume
40
Category
Article
ISSN
0014-2980

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## Abstract Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has recently been shown to promote caspase‐1 activation and IL‐1Ξ² secretion, but the cellular pathways involved remain elusiv