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Steric course of the addition of nucleophiles to 2-phenyl-1,3-dioxan-5-one

✍ Scribed by J.C. Jochims; Y. Kobayashi; E. Skrzelewski

Publisher
Elsevier Science
Year
1974
Tongue
French
Weight
195 KB
Volume
15
Category
Article
ISSN
0040-4039

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✦ Synopsis

Six-membered ring ketones such as 4 butyl-cyclohexanone, I, are attacked by nucleophiles (e.g., Grignard reagents or metal hydrides) from two different sites giving rise to products E with an equatorial OH group, and A with.an axial OH group. The ratio of the amounts the rate constants 1, 2) have recently been attributed two factors:

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