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Steric course and regioselectivity in the cycloadditions of diazoacetic ester to trans- and cis-cinnamic ester

✍ Scribed by Peter Eberhard; Rolf Huisgen


Publisher
Elsevier Science
Year
1971
Tongue
French
Weight
264 KB
Volume
12
Category
Article
ISSN
0040-4039

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## Abstract The first direct enzymatic method is reported for the synthesis of __cis__ and __trans__ β‐amino acid enantiomers through the lipase‐catalyzed enantioselective hydrolysis of alicyclic β‐amino esters in organic media. High enantioselectivities (__E__ usually >100) were observed when the