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The First Direct Enzymatic Hydrolysis of Alicyclic β-Amino Esters: A Route to Enantiopure cis and trans β-Amino Acids

✍ Scribed by Enikõ Forró; Ferenc Fülöp

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 115 KB
Volume: 13
Category: Article
ISSN: 0947-6539
DOI: 10.1002/chem.200700257

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✦ Synopsis

Abstract

The first direct enzymatic method is reported for the synthesis of cis and trans β‐amino acid enantiomers through the lipase‐catalyzed enantioselective hydrolysis of alicyclic β‐amino esters in organic media. High enantioselectivities (E usually >100) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H~2~O (0.5 equivalents) in __i__Pr~2~O at 65 °C. The resolved products, obtained in good yields (≥42 %), could be easily separated.

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